It's revealed that Wilson has been setting House up for dates with his team members as he's concerned for House's well-being. Taub invites House to dinner, Thirteen invites him to come with her to a lesbian bar, and House performs a karaoke rendition of " Midnight Train to Georgia" with Foreman and Chase. Meanwhile, House spends extracurricular time with his Princeton Plainsboro colleagues. She says she must make her choice and cannot marry him. He declares that he has chosen the life he wants to lead, that he loves his fiancée and wants to get married. His brain pressing against his pituitary caused the other symptoms. Ted's therapy caused his brain to swell just enough to plug the opening, cutting off his CSF. Ted has an Arnold–Chiari malformation, a narrowing in the base of his skull. The team checks his prolactin level and MRI his pituitary. Taub suggests a pituitary tumor which could explain his libido and heart issues, and if the tumor's big enough, the headaches and syncope as well. The test shows everything's normal with his penis' blood flow, but Ted starts to lactate. Taub suggests that arterial disease causing acute ischemia could explain the heart, neurological symptoms, and possibly even POTS. Nicole says Ted sometimes has erectile dysfunction, but Cotter claims they never had such problems. They get Nicole, Ted, and Cotter in the same room to redo Ted's history, hoping this time it will be more accurate. However, Ted's face twists in a strange way. Low pressure in the brain caused the POTS, not the other way around. House thinks the spinal tap caused Ted to spring a leak, worsening the headaches. But Ted tests negative for infections and his headaches get worse. House orders a spinal tap and says to run the CSF. It could also spread to the heart if it's fungal. Taub suggests cerebral infection, which would explain the headaches and cause POTS. At that moment, Ted starts to have a severe headache. Ted admits he used to think he was gay, but got help and insists he is straight now. Nicole then confronts Ted about exactly who Cotter is. While Ted is sleeping, Cotter comes to visit, but when he takes Ted's hand, Nicole asks him to leave.
House thinks it could be postural orthostatic tachycardia syndrome (POTS), causing his blood pressure to plummet when he's upright. The team comes in to prep Ted for his angio, but every time he sits up he faints, and he stabilizes when he lies down. Foreman decides to do an angiogram to see if it's blocks or bleeds. The team thinks the ECT could have caused head trauma. The chemicals could explain the pleural effusion and the ECT could explain the rest. He had electro convulsion therapy and was injected with many different chemicals. Thirteen talks to him and finds out he had "treatment" to become heterosexual. The team tests Ted for HIV/AIDS but he's negative. The owner, Cotter, claims to be Ted's ex-boyfriend of three years. Thirteen and Taub check where Ted lived before he moved into his fiancée's room, but the owner comes back and sees them. However, he has a pleural effusion as he's being discharged. House unexpectedly pokes him with a needle and Ted says "ow." House claims Ted was faking to avoid getting married. He fainted at his wedding after having a round of aphasia (loss of voice). The team takes on the case of an ailing groom-to-be (guest star Adam Garcia) named Ted.
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